Uses of Titanium Nitride Ceramic Materials in Biomedicine

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What is titanium Nitride?

Titanium-nitride is a non-stoichiometric compound. It has a stable composition range of TiN0.37-TiN1.16, and the nitrogen content can be changed within a specific range without causing changes in the structure. TiN, a nonstoichiometric material, has a range of stable compositions between TiN0.37 and TiN1.16, with the nitrogen content being able to be adjusted within that range. The TiN Powder is usually yellow-brown. The ultrafine TiN Powder is black. TiN Crystals are golden yellow. TiN has melting points of 2950degC and a density between 5.43-5.44g/cm3. It also has a Mohs Hardness of 8-9 as well as high thermal shock resistance. TiN’s melting points are higher than those of most transition-metal nitrides. The density of TiN is lower than the majority metal nitrides. This makes it a material that is very heat resistant. The TiN crystallization is similar to TiC’s, but the C atoms have been replaced by N atoms.

Titanium Nitride as a Biomedical Material

Clinical medicine has widely used the occluder for the treatment of congenital diseases, such as the atrial septal defect, ventricular septal defect and patent arteriosus. Most common concentrics occluders contain nickel up to a maximum of 55% in nickel-titanium metal alloys. The body can become poisoned and allergic to nickel, which in turn may cause cancer. The surface membrane of the occluder Nickel-Titanium alloy may be destroyed. In addition, the release of nickel ions from the human body’s complex environment can increase the nickel content.

According to relevant studies, because titanium nitride is a biocompatible material (and was previously used in coronary-stents), thrombus formation is lower than with nickel-titanium. To address this problem, scientists developed a Cera Ceramic Membrane Occluder, using high-energy coating technology. It maintains both the original interventricular and atrial septal septal occluders based on the original Nickel-Titanium Alloy occluder. The occluder design and patent ductus archeteriosus occluder use plasma technology to evenly apply a titanium nitride (TiN) film onto the surface of nickel-titanium alloy powder. Using ion technologies, the metal Titanium coating and C N O and other compound are transformed into The biological Layer dramatically improves corrosion resistance and compatibility with biological tissue and blood. The comparison of the data from animal experiments shows that the Cera membrane occluder has a much higher performance in terms cell creeping growth compared to the normal nickel-titanium. It significantly reduces thrombosis risk and helps repair congenital heart defects. Platelet adhesion rates and hemolysis are also lower compared to the nickel-titanium standard occluder. Cera’s occluder was approved by other countries, including the European Union, India and Brazil. The Cera occluder has been used by more than thousands patients with congenital hearts disease.


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